---
title: "Priors"
output:
  rmarkdown::html_vignette:
vignette: >
  %\VignetteIndexEntry{Priors}
  %\VignetteEngine{knitr::rmarkdown}
  %\VignetteEncoding{UTF-8}
bibliography: bayesnec.bib
---



## Overview

The main focus here is to explain the default priors used in `bayesnec` and to showcase how the user can interrogate the priors used in a `bayesec` model and alternatively specify their own priors, should they wish to. This might be needed depending on the model and the data because `bayesnec` tries to find reasonable and yet only weakly informative priors for the model parameters by default. First we describe the default priors used in `bayesnec` and then follow up with a demonstration of how the user can specify priors in multiple ways for objects of class `bayesnecfit` and `bayesmanecfit`.

## Default priors in `bayesnec`

The default priors used in `bayesnec` can generally be considered "weakly informative". They are constructed for each parameter of each model being fitted based on the characteristics of either the input response and predictor data, depending on which is relevant to the specific parameter scaling. In the case of parameters that scale with the response, priors are constructed based on the relevant link scaling, whether that be identity or the default (or user specific) link function for a specific distribution. The priors are constructed by `bnec` internally based on the chosen model, the distribution (including the relevant link function), the predictor and the response.

### Priors for response-scaled parameters

Only the parameters **top** and **bot** scale specifically with the response. For Gaussian-distributed response data (or any response data for which the link ensures valid values of the response can take from `+Inf` to `-Inf`, including `log` and `logit`) priors are `normal` with a standard deviation of `2.5` times the standard deivation of the response data, and a mean set at the 90^th^ and 10^th^ quantiles for **top** and **bot** respectively. For Poisson-, Negative Binomial- and Gamma-distributed data the response is bounded by `0` and thus priors are `Gamma`, with a mean scaled to correspond to the 75^th^ and 25^th^ quantiles for **top** and **bot** respectively. The mean is linked mathematically to the shape (*s*) and rate parameters (*r*) by the equation $mean = s \times (1/r)$ with the Gamma shape parameter set at 2. For the Binomial, Beta, and Beta Binomial families estimates for **top** and **bot** must necessarily be constrained between `0` and `1` when modelled on the `"identity"` link (the default in `bayesnec`). Because of this constraint there is no need to adjust scaling based on the response. `bayesnec` uses `beta(5, 2)` and `beta(2, 5)` priors to provide a broad density centred across the upper and lower `0` to `1` range for the **top** and **bot** parameters, respectively.

### Priors for predictor-scaled parameters

The parameters **nec** and **ec50** scale with respect to the predictor because both of these are parameters in concentration-response curves the are estimated in units of concentration. To stabilise model fitting the **nec** and **ec50** parameters are bounded to the upper and lower observed range in the predictor, under the assumption that the range of concentrations in the experiment were sufficient to cover the full range of the response outcomes. The priors used reflect the characteristics of the observed data that are used to guess the appropriate distribution. If the predictor data are bounded to `0` and  `>1`, a `Gamma` prior is used, with maximum density (mean, see above) at the median value of the predictor, and a shape parameter of 5. If the predictor data are bounded to `0` and `1` a `beta(2, 2)` prior is used. For predictor data ranging from `+Inf` to `-Inf` a `normal` prior is used, with a mean set at the median of the predictor values and a standard deviation of 10 times the standard deviation of the predictor values.

### Priors for other parameters

For the parameters **beta**, **slope**, **d** and **f**, we first ensured any relevant transformations in the model formula such that theoretical values of `-Inf` to `+Inf` are allowable, and a `normal(0, 5)` prior is used. For example, in the **nec3param** model, **beta** is an exponential decay parameter which must by definition be bounded to `0` and `+Inf`. Calling `exp(beta)` in the model formula ensures the exponent meets these requirements. Note also that a mean of `0` and standard deviation of `5` represents a relatively broad prior on the exponential scaling. See the **Model details** vignette or `?model("all")` for more information on all the models available in `bayesnec` and their specific formulation. 

## User specified priors

There may be situations were the default `bayesnec` priors to not behave as desired, or the user wants to provide informative priors. For example the default priors may be too informative, yielding unreasonably tight confidence bands, although this is only likely where there are few data. Conversely, priors may be too vague, leading to poor model convergence, or an inability of `bayesnec` to find appropriate starting values. Alternatively, as indicated in the example below, the default priors may be of the wrong statistical distribution if there was insufficient information in the provided data for `bayesnec` to guess correctly the appropriate one to use.

The priors used in the default model fit can be extracted using `pull_prior`, and a sample or plot of prior values can be obtained from the individual `brms` model fits through the function `sample_priors` which samples directly from the `prior` element in the `brm` model fit. We can also use the function `check_prior` (based on the `hypothesis` function of `brms`) to assess how the posterior probability density for each parameter differs from that of the prior.

### bayesnecfit

To set specified priors, it is simplest to start by letting `bnec` find the priors on its own, i.e. by not specifying the `brm` argument `prior` at all.




```r
library(brms)
library(bayesnec)
data(nec_data)

# a single model
set.seed(333)
exmp_a <- bnec(y ~ crf(x, model = "nec3param"), data = nec_data,
               family = Beta(link = "identity"),
               iter = 1e4, control = list(adapt_delta = 0.99))
```


```r
class(exmp_a)
#> [1] "bayesnecfit" "bnecfit"
```

We can view the prior and posterior probability densities of all the parameters in the model using the function `check_prior`, based on the `hypothesis` function of `brms`. This can be useful to assess if priors are suitably vague, and/or if they might be having an undesirable influence on the posterior.


```r
check_priors(exmp_a)
```

<img src="vignette-fig-exmp3-checkpriors-1.png" alt="plot of chunk exmp3-checkpriors" width="100%" style="display: block; margin: auto;" />

In this case the priors seem reasonably vague, however there will be times when it is necessary to modify these priors. The user can take advantage of the function `pull_prior` to inspect what `bnec` came up with on its own, and decide how best to modify those priors to be more desirable.


```r
pull_prior(exmp_a)
#> [[1]]
#>                       prior class      coef group resp dpar nlpar               lb               ub
#>                normal(0, 5)     b                            beta                                  
#>                normal(0, 5)     b Intercept                  beta                                  
#>  gamma(5, 2.28313180499098)     b                             nec 0.03234801324009 3.22051966293556
#>  gamma(5, 2.28313180499098)     b Intercept                   nec 0.03234801324009 3.22051966293556
#>                  beta(5, 2)     b                             top                0                1
#>                  beta(5, 2)     b Intercept                   top                0                1
#>           gamma(0.01, 0.01)   phi                                                0                 
#>        source
#>          user
#>  (vectorized)
#>          user
#>  (vectorized)
#>          user
#>  (vectorized)
#>       default
```

`bnec` chose a `gamma` prior on the *NEC* parameter of **nec3param** because the predictor `nec_data$x` is non-zero positive. However, imagine that in theory the predictor could have had negative values, it just happened to not have in this particular dataset. So let's go ahead and specify something else, say a normal with larger variance.


```r
set.seed(333)
my_prior <- c(prior_string("beta(5, 1)", nlpar = "top"),
              prior_string("normal(1.3, 2.7)", nlpar = "nec"),
              prior_string("gamma(0.5, 2)", nlpar = "beta"))
exmp_b <- bnec(y ~ crf(x, model = "nec3param"), data = nec_data,
               family = Beta(link = "identity"), prior = my_prior,
               iter = 1e4, control = list(adapt_delta = 0.99))
```

Two things are of note. If the user is specifying their own priors, `bnec` requires them to specify priors for **all** parameters. The `pull_prior` function shows the priors *after* the model was fitted, but suppose the user does not know what parameters were comprised in a particular model. In those instances, the user can call the function `show_params(model = "all")` to inspect the parameters of each function, or some targeted function in particular.


```r
show_params(model = "nec3param")
#> [[1]]
#> y ~ top * exp(-exp(beta) * (x - nec) * step(x - nec)) 
#> top ~ 1
#> beta ~ 1
#> nec ~ 1
```

### bayesmanecfit

The user can also specify a named list of priors when one or more models are being fitted to the same dataset.


```r
set.seed(333)
my_priors <- list(nec3param = c(prior_string("beta(5, 1)", nlpar = "top"),
                                prior_string("normal(1.3, 2.7)", nlpar = "nec"),
                                prior_string("gamma(0.5, 2)", nlpar = "beta")),
                  nec4param = c(prior_string("beta(5, 1)", nlpar = "top"),
                                prior_string("normal(1.3, 2.7)", nlpar = "nec"),
                                prior_string("gamma(0.5, 2)", nlpar = "beta"),
                                prior_string("beta(1, 5)", nlpar = "bot")))
exmp_c <- bnec(y ~ crf(x, model = c("nec3param", "nec4param")), data = nec_data,
               family = Beta(link = "identity"), prior = my_priors,
               iter = 1e4, control = list(adapt_delta = 0.99))
```

`pull_prior` also works for an object of class `bayesmanecfit`, as does `check_priors` which allows an option of passing a filename to save the prior and posterior probability density plots to a pdf.


```r
pull_prior(exmp_c)
check_priors(exmp_c, filename = "Check_priors")
```


```
#> $nec3param
#>              prior class      coef group resp dpar nlpar lb ub       source
#>      gamma(0.5, 2)     b                            beta               user
#>      gamma(0.5, 2)     b Intercept                  beta       (vectorized)
#>   normal(1.3, 2.7)     b                             nec               user
#>   normal(1.3, 2.7)     b Intercept                   nec       (vectorized)
#>         beta(5, 1)     b                             top               user
#>         beta(5, 1)     b Intercept                   top       (vectorized)
#>  gamma(0.01, 0.01)   phi                                  0         default
#> 
#> $nec4param
#>              prior class      coef group resp dpar nlpar lb ub       source
#>      gamma(0.5, 2)     b                            beta               user
#>      gamma(0.5, 2)     b Intercept                  beta       (vectorized)
#>         beta(1, 5)     b                             bot               user
#>         beta(1, 5)     b Intercept                   bot       (vectorized)
#>   normal(1.3, 2.7)     b                             nec               user
#>   normal(1.3, 2.7)     b Intercept                   nec       (vectorized)
#>         beta(5, 1)     b                             top               user
#>         beta(5, 1)     b Intercept                   top       (vectorized)
#>  gamma(0.01, 0.01)   phi                                  0         default
```

The user can also specify priors for one model only out of the entire set, `bayesnec` will return a message stating that it is searching for priors on its own when they are either ill-formed (e.g. incomplete or have a typo), or the user simply decided not to specify priors for a particular model, e.g.


```r
set.seed(333)
my_priors <- list(nec3param = c(prior_string("beta(5, 1)", nlpar = "top"),
                                prior_string("normal(1.3, 2.7)", nlpar = "nec"),
                                prior_string("gamma(0.5, 2)", nlpar = "beta")),
                  nec4param = c(prior_string("beta(5, 1)", nlpar = "top"),
                                prior_string("normal(1.3, 2.7)", nlpar = "nec"),
                                prior_string("gamma(0.5, 2)", nlpar = "beta"),
                                prior_string("beta(1, 5)", nlpar = "bot")))
exmp_d <- bnec(y ~ crf(x, model = c("nec3param", "nec4param")), data = nec_data,
               family = Beta(link = "identity"), prior = my_priors[1],
               iter = 1e4, control = list(adapt_delta = 0.99))
```

`prior = my_priors[[1]]` would also have worked because the argument priors can either take a `brmsprior` object directly, or a named list containing model-specific `brmsprior` objects.

Finally the user can also extend an existing `bayesmanecfit` object with the function `amend`, also by specifying custom-built `priors`.


```r
set.seed(333)
necsigm_priors <- c(prior_string("beta(5, 1)", nlpar = "top"),
                    prior_string("gamma(2, 6.5)", nlpar = "beta"),
                    prior_string("normal(1.3, 2.7)", nlpar = "nec"),
                    prior_string("normal(0, 2)", nlpar = "d"))
exmp_e <- amend(exmp_d, add = "necsigm", priors = necsigm_priors)
```
