# Group Sequential Design with Non-Constant Effect

## Documentation for package ‘gsDesign2’ version 1.0.7

- DESCRIPTION file.
- User guides, package vignettes and other documentation.

## Help Pages

ahr | Average hazard ratio under non-proportional hazards (test version)
as_gt | Convert summary table of a fixed or group sequential design object to a gt object
as_gt.fixed_design | Convert summary table of a fixed or group sequential design object to a gt object
as_gt.gs_design | Convert summary table of a fixed or group sequential design object to a gt object
expected_accrual | Piecewise constant expected accrual
expected_event | Expected events observed under piecewise exponential model
expected_time | Predict time at which a targeted event count is achieved
fixed_design | Fixed design sample size
gridpts | Grid points for group sequential design numerical integration
gs_b | Default boundary generation
gs_create_arm | Create npsurvSS arm object
gs_design_ahr | Group sequential design using average hazard ratio under non-proportional hazards
gs_design_combo | Group sequential design using MaxCombo test under non-proportional hazards
gs_design_npe | Group sequential design computation with non-constant effect and information
gs_design_rd | Group sequential design using average hazard ratio under non-proportional hazards
gs_design_wlr | Group sequential design using weighted log-rank test under non-proportional hazards
gs_info_ahr | Information and effect size based on AHR approximation
gs_info_combo | Information and effect size for MaxCombo test
gs_info_rd | Information and effect size under risk difference
gs_info_wlr | Information and effect size for weighted log-rank test
gs_power_ahr | Group sequential design power using average hazard ratio under non-proportional hazards
gs_power_combo | Group sequential design power using MaxCombo test under non-proportional hazards
gs_power_npe | Group sequential bound computation with non-constant effect
gs_power_rd | Group sequential design power under risk difference
gs_power_wlr | Group sequential design power using weighted log rank test under non-proportional hazards
gs_spending_bound | Derive spending bound for group sequential boundary
gs_spending_combo | Derive spending bound for MaxCombo group sequential boundary
h1 | Initialize numerical integration for group sequential design
hupdate | Update numerical integration for group sequential design
ppwe | Piecewise exponential cumulative distribution function
s2pwe | Approximate survival distribution with piecewise exponential distribution
summary.fixed_design | Summary for fixed design or group sequential design objects
summary.gs_design | Summary for fixed design or group sequential design objects
to_integer | Rounds sample size to an even number for equal design
to_integer.fixed_design | Rounds sample size to an even number for equal design
to_integer.gs_design | Rounds sample size to an even number for equal design
wlr_weight | Weight functions for weighted log-rank test
wlr_weight_1 | Weight functions for weighted log-rank test
wlr_weight_fh | Weight functions for weighted log-rank test
wlr_weight_mb | Weight functions for weighted log-rank test
wlr_weight_n | Weight functions for weighted log-rank test