Type: Package
Package: nlmixr2est
Title: Nonlinear Mixed Effects Models in Population PK/PD, Estimation
        Routines
Version: 2.1.3
Authors@R: c(
    person("Matthew", "Fidler", , "matthew.fidler@gmail.com", role = c("aut", "cre"),
           comment = c(ORCID = "0000-0001-8538-6691")),
    person("Yuan", "Xiong", , "yuan.xiong@gmail.com", role = "aut"),
    person("Rik", "Schoemaker", , "rik.schoemaker@occams.com", role = "aut",
           comment = c(ORCID = "0000-0002-7538-3005")),
    person("Justin", "Wilkins", , "justin.wilkins@occams.com", role = "aut",
           comment = c(ORCID = "0000-0002-7099-9396")),
    person("Wenping", "Wang", , "wwang8198@gmail.com", role = "aut"),
    person("Robert", "Leary", role = "ctb"),
    person("Mason", "McComb", , "mason.c.mccomb@gmail.com", role = "ctb",
           comment = c(ORCID = "0000-0001-9871-8616")),
    person("Vipul", "Mann", , "vm2583@columbia.edu", role = "aut"),
    person("Mirjam", "Trame", , "mirjam.trame@gmail.com", role = "ctb"),
    person("Mahmoud", "Abdelwahab", , "mah.tareq87@gmail.com", role = "ctb"),
    person("Teun", "Post", , "t.post@lapp.nl", role = "ctb"),
    person("Richard", "Hooijmaijers", , "richardhooijmaijers@gmail.com", role = "aut"),
    person("Hadley", "Wickham", role = "ctb"),
    person("Dirk", "Eddelbuettel", , "edd@debian.org", role = "cph"),
    person("Johannes", "Pfeifer", role = "ctb"),
    person("Robert B.", "Schnabel", role = "ctb"),
    person("Elizabeth", "Eskow", role = "ctb"),
    person("Emmanuelle", "Comets", , "emmanuelle.comets@inserm.fr", role = "ctb"),
    person("Audrey", "Lavenu", role = "ctb"),
    person("Marc", "Lavielle", role = "ctb"),
    person("David", "Ardia", role = "cph"),
    person("Katharine", "Mullen", role = "cph"),
    person("Ben", "Goodrich", role = "ctb")
  )
Maintainer: Matthew Fidler <matthew.fidler@gmail.com>
Description: Fit and compare nonlinear mixed-effects models in
    differential equations with flexible dosing information commonly seen
    in pharmacokinetics and pharmacodynamics (Almquist, Leander, and
    Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation
    solving is by compiled C code provided in the 'rxode2' package (Wang,
    Hallow, and James 2015 <doi:10.1002/psp4.12052>).
License: GPL (>= 3)
URL: https://github.com/nlmixr2/nlmixr2est,
        https://nlmixr2.github.io/nlmixr2est/
Depends: nlmixr2data, R (>= 4.0)
Imports: backports, checkmate, cli, graphics, knitr, lbfgsb3c, lotri,
        magrittr, Matrix, methods, minqa, n1qn1 (>= 6.0.1-10), nlme,
        Rcpp, rex, Rvmmin, rxode2 (>= 2.0.10), stats, symengine,
        ucminf, utils, vpc
Suggests: broom.mixed, crayon, data.table, devtools, digest, dplyr,
        generics, nloptr, qs, sys, testthat, tibble, withr, xgxr,
        sfsmisc, rxode2parse (>= 2.0.11), rxode2random (>= 2.0.9)
LinkingTo: BH, lbfgsb3c, Rcpp, RcppArmadillo (>= 0.11.2.3.1), RcppEigen
        (>= 0.3.3.3.0), rxode2 (>= 2.0.10), StanHeaders (>= 2.18.0),
        rxode2parse (>= 2.0.11), rxode2random (>= 2.0.9)
Biarch: true
Config/testthat/edition: 3
Encoding: UTF-8
Language: en-US
NeedsCompilation: yes
RoxygenNote: 7.2.1
Packaged: 2022-11-10 15:28:13 UTC; matt
Author: Matthew Fidler [aut, cre] (<https://orcid.org/0000-0001-8538-6691>),
  Yuan Xiong [aut],
  Rik Schoemaker [aut] (<https://orcid.org/0000-0002-7538-3005>),
  Justin Wilkins [aut] (<https://orcid.org/0000-0002-7099-9396>),
  Wenping Wang [aut],
  Robert Leary [ctb],
  Mason McComb [ctb] (<https://orcid.org/0000-0001-9871-8616>),
  Vipul Mann [aut],
  Mirjam Trame [ctb],
  Mahmoud Abdelwahab [ctb],
  Teun Post [ctb],
  Richard Hooijmaijers [aut],
  Hadley Wickham [ctb],
  Dirk Eddelbuettel [cph],
  Johannes Pfeifer [ctb],
  Robert B. Schnabel [ctb],
  Elizabeth Eskow [ctb],
  Emmanuelle Comets [ctb],
  Audrey Lavenu [ctb],
  Marc Lavielle [ctb],
  David Ardia [cph],
  Katharine Mullen [cph],
  Ben Goodrich [ctb]
Repository: CRAN
Date/Publication: 2022-11-10 17:00:19 UTC
Built: R 4.1.3; x86_64-w64-mingw32; 2023-03-30 22:23:49 UTC; windows
Archs: i386, x64
