News for Package ncar

Changes in version 0.7.0 (2026-06-20)

• pdfIQ added: generates a self-contained Installation Qualification (IQ) report in pdf that documents whether ncar and NonCompart are correctly installed, intact, loadable, and operational in the user's R environment (environment, package versions, dependency satisfaction, MD5 file integrity, namespace/exports, a functional NCA check against an external reference, and an overall QUALIFIED/NOT QUALIFIED verdict with a sessionInfo appendix).

• pdfOQ added: generates a self-contained Operational Qualification (OQ) report in pdf. It runs a set of NCA test cases (eight WinNonlin-referenced scenarios shipped in ‘inst/OQ’) through tblNCA on the user's machine and compares every parameter for every subject to the pre-specified reference within a relative tolerance. The report lists every computed value next to its reference value, the absolute and relative difference, and a pass flag, with an overall QUALIFIED/NOT QUALIFIED verdict.

• writeMD5 added: writes the standard R ‘MD5’ integrity manifest into an installed package directory (using tools::md5sum), so that the pdfIQ file-integrity check reports PASS for local installs. CRAN installs already include this manifest.

• pdfPQ added: a Performance Qualification (PQ) report generator. It runs the analysis the user intends on the user's own data and checks reproducibility, per-profile scientific plausibility, and (optionally) agreement with the user's expected values, with an input-data md5 fingerprint and a signed record.

• pdfNCA now prints “Performed by” / “Reviewed by” approval lines (and an optional performedBy name) on the first page.

• addSigField added (and a sigField argument to pdfIQ/pdfOQ/pdfPQ): insert Adobe Acrobat Reader signature fields into the report PDF (pure base-R PDF incremental update, no external tools) so it can be signed with one click in the free Acrobat Reader, instead of printing and scanning.

• signPDF and verifyPDF added: digitally sign a report PDF (a detached SHA-256 signature written to ‘<pdf>.sig’, using the openssl package) and verify it, as a scriptable alternative.

• The IQ and OQ reports use 1 inch margins on every side, select Letter paper in a United States locale and A4 elsewhere (paper argument), place the signature/approval page first, and include a per-file md5 checksum appendix (IQ).

Changes in version 0.6.1 (2026-06-19)

• The dependency on the archived rtf package was removed. The subset of rtf functions required by rtfNCA is now vendored internally in ‘R/rtf_utils.R’ (originally authored by Michael E. Schaffer, GPL (>= 2)).

Changes in version 0.6.0 (2026-04-26)

• txtNCA, pdfNCA, and rtfNCA support indices of points (UsePoints) to calculate terminal slope.

Changes in version 0.5.1 (2026-03-27)

• pdfNCA and rtfNCA support vector input for dur argument.

• Four errata fixed.

Changes in version 0.5.0 (2023-11-11)

• SS option for steady-state added in txtNCA, pdfNCA and rtfNCA.

Changes in version 0.4.5 (2022-02-23)

• Problem with tbl_df in pdfNCA and rtfNCA function is fixed.

Changes in version 0.4.4 (2021-07-09)

• mayExcludeLast option added to pdfNCA, rtfNCA, txtNCA. This option works with NonCompart 0.4.9 or later.

Changes in version 0.4.3 (2021-06-11)

• Handles NA better with less error in the plot.

Changes in version 0.4.2 (2018-09-27)

• Some sentences are revised.

Changes in version 0.4.1 (2018-07-20)

• Argument key replaced key in rtfNCA and pdfNCA function.

Changes in version 0.4.0 (2018-06-20)

• Deprecated option in Sys.timezone(). is removed.

Changes in version 0.3.9 (2018-05-10)

• Calling twice for terminal slope is corrected.

Changes in version 0.3.8 (2018-04-10)

• Errata in manual corrected.

Changes in version 0.3.7 (2017-08-16)

• ncar to be compatible with NonCompart_0.3.3.

Changes in version 0.3.6 (2017-07-18)

• ncar A bug in C0 calcuation of IV bolus case was fixed.

Changes in version 0.3.5 (2017-07-10)

• ncar depends on NonCompart

Changes in version 0.3.4 (2017-03-12)

• ncar does not sort subject ID any more.

Changes in version 0.3.3 (2017-03-12)

• Various report functions like pdfNCA, rtfNCA, and txtNCA are added.

• IndiNCA and NCA are deprecated.