Dependencies are managed by ebuild.
--- a/cmake/virtualenv.cmake
+++ b/cmake/virtualenv.cmake
@@ -27,14 +27,6 @@ endfunction()
 
 function(virtualenv_install)
     virtualenv_create()
-    execute_process(
-      COMMAND ${VIRTUALENV_BIN_DIR}/${VIRTUALENV_PYTHON_EXENAME} -m pip install --upgrade pip
-      COMMAND_ECHO STDOUT
-    )
-    execute_process(
-      COMMAND ${VIRTUALENV_BIN_DIR}/${VIRTUALENV_PYTHON_EXENAME} -m pip install --upgrade setuptools
-      COMMAND_ECHO STDOUT
-    )
     execute_process(
       COMMAND ${VIRTUALENV_BIN_DIR}/${VIRTUALENV_PYTHON_EXENAME} -m pip install ${ARGN}
       COMMAND_ECHO STDOUT
--- a/tensilelite/setup.py
+++ b/tensilelite/setup.py
@@ -51,7 +51,7 @@ setup(
   url="https://github.com/RadeonOpenCompute/Tensile",
   author="Advanced Micro Devices",
   license="MIT",
-  install_requires=readRequirementsFromTxt(),
+  install_requires=[],
   python_requires='>=3.5',
   packages=["Tensile"],
   package_data={ "Tensile": ["Tensile/cmake/*"] },